5th International Synthetic & Systems Biology Summer School
July 25-29, 2018
Certosa di Pontignano
Tuscany - Hills
Certosa di Pontignano - School Venue
Florence - Old Bridge
Pisa - Leaning Tower
Certosa di Pontignano - School Venue
About the School
Recent advances in DNA synthesis have increased our ability to build biological systems. Synthetic Biology aims at streamlining the design and synthesis of robust and predictable biological systems using engineering design principles. Designing biological systems requires a deep understanding of how genes and proteins are organized and interact in living cells: Systems Biology aims at elucidating the cellular organization at gene, protein and network level using computational and biochemical methods.
The Synthetic and Systems Biology Summer School (SSBSS) is a full-immersion five-day residential summer school at the Certosa di Pontignano (Siena – Tuscany, Italy) on cutting-edge advances in systems and synthetic biology with lectures delivered by world-renowned experts. The school provides a stimulating environment for students (from Master students to PhD students), Post-Docs, early career researches, academics and industry leaders. Participants will also have the chance to present their results, and to interact with their peers, in a friendly and constructive environment.
Given the rapidity with which this field moves, it is challenging for both newcomers and experts alike to stay updated with all of the latest advances. The goal of this summer school and workshop is to bring together scientists from academia and industry with diverse but relevant expertise in a setting conducive to discussion of new results and potential collaborative efforts. Invited talks will cover a wide range of topics ranging from fundamental basic science through to applications. Attendees of this workshop will have the opportunity to hear about the latest findings in this fast-paced field and to establish collaborations with scientists who have complementary expertise.
The Summer School will involve a total of 36-40 hours of lectures, according to the academic system the final achievement will be equivalent to 8 ECTS points for the PhD Students and the Master Students attending the summer school; during the summer school the students will tackle homeworks/projects.
Sessions integrate the recent achievements made in the fields of synthetic biology, systems biology, control engineering for synthetic biology, biochemical engineering, synthetic enzyme, evolutionary engineering, integrated omics, tools and methods, and emerging techniques, healthcare, biofuels, chemicals and materials, biologics, microbial and mammalian systems, and other disciplines and applications.
Call for Abstract/Poster submissions should be related to the following areas of synthetic biology, systems biology, genome and genetic engineering:
Intracellular processes are controlled in many ways. One way consists in placing proteins in the right place at the right time. For instance, transcription factors (TFs) are often kept cytoplasmic... Read More
Biological processes are carried out by complex networks of interacting proteins that continuously adapt to cellular environment and external stimuli with structural changes, which lead to new functional properties and... Read More
Synthetic biology seeks to probe fundamental aspects of biological form and function by construction (i.e. resynthesis) rather than deconstruction (analysis). Synthesis thus complements reductionist and analytic studies of life, and... Read More
One of the major challenges in biology concerns the integration of data across length and time scales into a consistent framework: how do macroscopic properties and functionalities arise from the... Read More
In the second lecture, I will focus on epithelial organisation. Epithelial cells adhere tightly, forming a polygonal lattice. The resulting cell packing exhibits striking universal regularities, regardless of the organism... Read More
Whole-cell (WC) computational models that predict phenotype from genotype are needed to help bioengineers rationally design bacteria and other organisms. Despite their potential, numerous challenges remain to achieve WC models.... Read More
Recently, we and others demonstrated the feasibility of WC models by developing the first model that captures the function of each individual gene. However, it took over 10 person-years to... Read More
Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use a holistic approach for studying metabolism. With the advancement of different omics technologies... Read More
Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies, the use of mathematical models in biology is... Read More
The remarkable efforts recently carried out to fully understand the mutational landscape of various cancer types have motivated the development of many computational approaches to interpret cancer genomic data. This... Read More
By analysing the catalogue of the somatic mutations present in several cancer genomes it is possible to understand the mutational processes active in different tumours. This session will introduce some... Read More
With the wealth of omics data that is rapidly and continuously being generated, new computational methods are required to interpret data-centric studies aiming to integrate multiple omics data types. This... Read More
Cancer has been well established as a disease of the genome, with a subset of somatic mutations frequently acting as drivers of tumor progression, and thereby influencing diagnosis, prognosis and... Read More
Here, I will present background on health-related problems that can be addressed by synthetic and systems biology. I will present a personal case study on development of a cancer therapeutic... Read More
One major thrust for synthetic biologists is to harness the ability natural chemical processes to create a more sustainable industry for chemicals, consumables, materials and energy. I will cover new... Read More
Recent advances in genome engineering have enabled an unprecedented scale, accuracy, and ease to manipulate bacterial and eukaryotic genomes. In this lecture, I will discuss key contemporary methods for genome... Read More
Recording environmental and biological information across cell populations over time enables new systems for biosurveillance and cellular sentinels. In this lecture, I will discuss the framework to chronicle cellular events... Read More
Cell division cycle and metabolism are coupled networks. Cell growth and division require synthesis of macromolecules which is dependent on metabolic cues. Conversely, metabolites involved in storage metabolism fluctuate periodically... Read More
In recent years, single-cell technologies, both at imaging and sequencing level, have given the possibility to observe how tissues and organs are spatially and temporally organized as a system of... Read More
Random variability in gene expression (noise) might severely impact on cellular behaviours. At odds with other engineering applications, where noise is usually associated with a deterioration of the functional properties,... Read More
The application of synthetic biology tools to investigate phenotypic variability has provided insight into the regulatory mechanisms that tune biological noise in natural networks. The efficiency of these mechanisms has... Read More
Synthetic biology has emerged as a powerful discipline that facilitates the manipulation of cells in a more reliable, predictable and standardized manner. Metabolic engineering aims to modify metabolic pathways to... Read More
The complexity of the proteome greatly outnumbers that of the genome and the diversity is mainly due to post-translational modifications (PTMs). Indeed, PTMs are fundamental regulators of many pathways and... Read More
Synthetic Biology aims at developing and applying engineering tools to sense and process endogenous information and to implement robust responses to intracellular conditions. Mammalian synthetic networks build on the conjugation... Read More