Lecture 2: Mutational Signatures in Environmental Carcinogen-Induced Tumours
By analysing the catalogue of the somatic mutations present in several cancer genomes it is possible to understand the mutational processes active in different tumours. This session will introduce some computational methods that have been developed to discover mutational signatures in cancer genomes. We will then study their application to identify the signature of mutational processes in the genome of mouse tumours following exposure to some carcinogens.