(Synthetic) gene circuit architecture control of microbial phenotypic variability
The application of synthetic biology tools to investigate phenotypic
variability has provided insight into the regulatory mechanisms that
tune biological noise in natural networks. The efficiency of these
mechanisms has inspired the selection of biological parts and
topologies that could control the behavioral dispersion of engineered
micro-organisms. Although further efforts are required, especially for
the characterization of extrinsic components, enhancing network
robustness could foster the design of innovative synthetic devices,
with potential benefits in bioremediation, biomedicine and
biotechnology.