5th International Synthetic & Systems Biology Summer School   |   Certosa di Pontignano - Siena - Tuscany - Italy   |  July 25-29, 2018

Lectures

Lectures

Day 1
24 Apr 2018

Lecture 1: Systems Biology of Yeast Metabolism: Big Data Generation

Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use a holistic approach for studying metabolism. With the advancement of different omics technologies...
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Jens Nielsen

Lecture 2: Systems Biology of Yeast Metabolism: Modeling

Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies, the use of mathematical models in biology is...
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Jens Nielsen

Lecture 1: Multiomics Integration in Cancer

Cancer has been well established as a disease of the genome, with a subset of somatic mutations frequently acting as drivers of tumor progression, and thereby influencing diagnosis, prognosis and...
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Kelly V. Ruggles

Lecture 2: Exploratory Analysis of Metagenomics Data

The human microbiome has been implicated in multiple diseases over the past decade and the identification of microbial features, including taxa and gene families, characterizing a specific disease is an...
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Kelly V. Ruggles

Lecture 1: Designing Biology for Health

Here, I will present background on health-related problems that can be addressed by synthetic and systems biology. I will present a personal case study on development of a cancer therapeutic...
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Pamela Silver

Lecture 2: Designing Biology for Sustainability

One major thrust for synthetic biologists is to harness the ability natural chemical processes to create a more sustainable industry for chemicals, consumables, materials and energy. I will cover new...
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Pamela Silver

Lecture 1: Multiplex Genome Engineering: Methods and Applications

Recent advances in genome engineering have enabled an unprecedented scale, accuracy, and ease to manipulate bacterial and eukaryotic genomes. In this lecture, I will discuss key contemporary methods for genome...
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Harris Wang

Lecture 2: Cellular Recording and Memory: Approaches and Uses

Recording environmental and biological information across cell populations over time enables new systems for biosurveillance and cellular sentinels. In this lecture, I will discuss the framework to chronicle cellular events...
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Harris Wang

Talks

Day 1
24 Apr 2018

Deciphering Cell’s Robustness by a Multi-scale Framework Integrating Cell Cycle and Metabolism in Budding Yeast

Cell cycle and metabolism are coupled networks. Cell growth and division require synthesis of macromolecules which is dependent on metabolic cues. Conversely, metabolites involved in storage carbon-, lipid- and nucleotide...
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Matteo Barberis

Talk: TBA

Barbara Di Camillo

Talk: TBA

Cristina Di Primio

Modelling noise in the design of synthetic gene networks

Random variability in gene expression (noise) might severely impact on cellular behaviours. At odds with other engineering applications, where noise is usually associated with a deterioration of the functional properties,...
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Simone Furini

(Synthetic) gene circuit architecture control of microbial phenotypic variability

The application of synthetic biology tools to investigate phenotypic variability has provided insight into the regulatory mechanisms that tune biological noise in natural networks. The efficiency of these mechanisms has...
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Emanuele Domenico Giordano

Synergies between synthetic biology and metabolic engineering for improving bioproduction

Synthetic biology has emerged as a powerful discipline that facilitates the manipulation of cells in a more reliable, predictable and standardized manner. Metabolic engineering aims to modify metabolic pathways to...
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Rodrigo Ledesma-Amaro