Deciphering Yeast Physiology by a Multi‐Scale Framework Integrating Cell Cycle and Metabolism
Cell division cycle and metabolism are coupled networks. Cell growth and division require synthesis of macromolecules which is dependent on metabolic cues. Conversely, metabolites involved... Read More
Designing New Tools for Synthetic Biology in Mammalian Cells
Synthetic Biology aims at developing and applying engineering tools to sense and process endogenous information and to implement robust responses to intracellular conditions. Mammalian synthetic... Read More
PISA Technology : a Novel Tool to Select Intrabodies to Target the Post-Translationally Modified Proteome in the Cell
The complexity of the proteome greatly outnumbers that of the genome and the diversity is mainly due to post-translational modifications (PTMs). Indeed, PTMs are fundamental... Read More
Synergies between synthetic biology and metabolic engineering for improving bioproduction
Synthetic biology has emerged as a powerful discipline that facilitates the manipulation of cells in a more reliable, predictable and standardized manner. Metabolic engineering aims... Read More
(Synthetic) gene circuit architecture control of microbial phenotypic variability
The application of synthetic biology tools to investigate phenotypic variability has provided insight into the regulatory mechanisms that tune biological noise in natural networks. The... Read More
Modelling Noise in the Design of Synthetic Gene Networks
Random variability in gene expression (noise) might severely impact on cellular behaviours. At odds with other engineering applications, where noise is usually associated with a... Read More
Designing Biosensors to Monitor Protein Folding and Aggregation
A growing number of diseases seem to be associated with toxic deposition of protein aggregates. Some of these diseases — such as Alzheimer’s disease— have... Read More
MAST: A Multi-Agent based Spatio-Temporal Model of the Interaction between Immune System and Tumor Growth Feeded with Single-Cell Data
In recent years, single-cell technologies, both at imaging and sequencing level, have given the possibility to observe how tissues and organs are spatially and temporally... Read More