By analysing the catalogue of the somatic mutations present in several cancer genomes it is possible to understand the mutational processes active in different tumours.... Read More

The remarkable efforts recently carried out to fully understand the mutational landscape of various cancer types have motivated the development of many computational approaches to... Read More

Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies, the use of... Read More

Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use a holistic approach for studying metabolism. With the... Read More

Recently, we and others demonstrated the feasibility of WC models by developing the first model that captures the function of each individual gene. However, it... Read More

Whole-cell (WC) computational models that predict phenotype from genotype are needed to help bioengineers rationally design bacteria and other organisms. Despite their potential, numerous challenges... Read More

In the second lecture, I will focus on epithelial organisation. Epithelial cells adhere tightly, forming a polygonal lattice. The resulting cell packing exhibits striking universal... Read More

One of the major challenges in biology concerns the integration of data across length and time scales into a consistent framework: how do macroscopic properties... Read More

A critical event in the origin of life is thought to have been the emergence of an RNA molecule capable of self-replication as well as... Read More

Synthetic biology seeks to probe fundamental aspects of biological form and function by construction (i.e. resynthesis) rather than deconstruction (analysis). Synthesis thus complements reductionist and... Read More