After working in Laboratories of Biophysics both in the United States and in Germany, in 1987 RC became Assistant Professor of Biophysics at the University of Bologna Italy. Since 1/10/2001 she is full professor of Biochemistry/Biophysics in the same University; RC has been working mainly in the fields of membrane and protein Biophysics (particularly with bacteriorhodopsin from Halobacterium Halobium and F1F0 ATPases from mesophilic organisms), both experimentally and theoretically. Presently she is interested in computer modelling of relevant biological processes, such as protein folding and modelling of their stability and interactions. One major field of research is the application of machine learning methods to the prediction of secondary and tertiary structure of proteins from their aminoacid residue sequences, particularly of membrane proteins and their transmembrane topology. one active research field is the annotation of mutations disease related and the prediction of their role at the level od structural systems biology. Presently she is the group leader of the Biocoputing Unit of the Interdipartimental Centre for Biotechnological Researches (CIRB) of the University of Bologna, Italy and her researches are devoted to different aspects of protein modelling, including prediction of secondary and tertiary structures with neural networks, hidden Markov models, genetic algorithms, molecular docking, protein reaction mechanisms and de novo design of helical peptides. At present the focus is mainly the implementation of integrated platforms for genome/proteome annotation, sequence annotation after alternative splicing in the human proteome, prediction of the relation of protein folding, misfolding and deseases in humans, search for SNPs in different genomes and their validation. RC is the author of about 300 scientific papers and presented her work at several (over 300) national and international meetings.